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Proteomics

 

 

What powers Proteomics?

Mass spec-based technologies (such as proteomics and metabolomics) play a key role in discovery approaches in the post-genomics era. Based on the advances that have been made in the field of mass spectrometry (MS), MS-based biomarker discovery is increasingly critical in identifying and developing diagnostics, as well as, for shortening drug development cycles.

What is Proteomics?

Proteomics is the study of the proteins present in a cell, tissue or organism. Different approaches within this field can be used to generate a global study of proteins present within a sample or look specifically at only a subsection of proteins.

Untargeted, or discovery proteomics, is a hypothesis-generating process which aims to analyse as many proteins as possible. This includes various workflows which can be qualitative in nature, such as protein identification or semi-quantitative, such as labelled or label-free quantitative approaches.

On the other hand, targeted analysis is a hypothesis-driven process analysing a few proteins of interest. When combined with appropriate standards, this approach can generate highly accurate quantitative information on these proteins

Metabolomics & Metabolite Profiling

Metabolomics is the study of metabolites present in a sample. Comprehensive studies of the metabolome are known to be complex. This is as a result of the large diversity in the structure and makeup of metabolites, as well as the subsequent complex data analysis requirements.

As a result, most studies, therefore, target a few metabolites of interest which can be quantified with the help of appropriate internal and reference standards.

Technology and Equipment

Discover more about our technologies, available equipment and platform-specific project examples.

What We Offer?

Discovery-Based Analysis

Discovery proteomics utilises samples to generate hypotheses that can be further tested, with the identification and quantification of key proteins. Experimental design is key here to ensure studies are statistically powered effectively.

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Data Acquisition Types Workflows
Data dependant acquisition (DDA) Protein identification, label free quantitative analysis, SILAC and TMT/ITRAQ
Data independant acquisition (DIA) SWATH
Available through Diplomics network laboratories

Targeted-Based Analysis

Targeted proteomics detects proteins of interest with high sensitivity, quantitative accuracy and reproducibility.

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Data Acquisition Types Workflows
Multiple Reaction Monitoring (MRM) or Parallel reaction monitoring Protein or small molecule quantification

Workflow Overview

Every project is different; however, all our workflows include sample processing, data acquisition, data QC and processing as standard.

Pricing Structure

Explore our guideline for proteomic services or get in touch to receive an accurate quote for the work you require.

General Enquiries

Got a question about our services?

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Request a Cost Estimate

Ready to get started and launch a project?

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Cape Town, RSA