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CPGR introduces the Axiom® Microbiome Array, an easy, streamlined solution for microbial profiling. It enables researchers to detect all known microorganisms in a sample with a single assay. The Array provides species- and strain-level detection on a scalable platform with straightforward, easy-to-use software.

Using Axiom assay biochemistry, Axiom® Microbiome Solution interrogates non-polymorphic sequences in both family-conserved and target-specific regions from NCBI database sequences. Axiom Microbiome Array detects over 12,000 organisms including archaea, bacteria, fungi, protozoa, and viruses. The array content is sample-type agnostic, suitable for applications in nutrigenomics, agrigenomics, and animal research.

Axiom Array Organisms

Key features of the array are:

  • 12,000 organisms on pan-microbial array
  • Species, strain and sequence level resolution
  • Scalable platform (24, 96 formats)
  • Straight forward analysis software
  • Genetic profiling of all organisms present in a sample in one single assay (bacteria, virus, fungi, archaea, protozoa)
  • Higher accuracy than 16S sequencing
  • Multiple probes (35mers) were designed for each organism found in public databases
  • Available at the CPGR at R 2,199,- (inclusive of VAT) for orders of 96, or more, received by the 31st of December 2016.

Axiom array process

 

The Axiom® Micriobiome array supports a wide range of applications in a diversity of research areas:

Axiom Array Applications

The CPGR is a non-profit company located in Cape Town, South Africa, based on an initiative by the Department of Science and Technology (DST), and financially supported by the Technology Innovation Agency (TIA). The CPGR combines state-of-the-art information rich genomic and proteomic (‘omics’) technologies with bio-computational pipelines in an ISO 9001:2008 certified environment. It has recently launched an accelerator program, together with its first start-up, Tokeid Biotech, and founded Artisan Biomed, a commercial venture to implement Precision Medicine solutions in (South) Africa.

The CPGR is an integrated ‘omics’ service provider, built to leapfrog South Africa’s ability to conduct information-rich biomedical research onto a globally competitive level. Amongst others, the organization offers the following ‘omics’ capacity: Next-Generation Sequencing: NextSeq500 (1x), MiSeq (1x), MiniSeq (1x), IonTorrent PGM (2x), IonProton (1x), for sequencing projects; Microarrays: Affymetrix GS 3000 and Affymetrix GeneTitan™ for genoytping and gene-expression analysis; Mass spectrometry: ABI 4800 MALDI TOF/TOF, Thermo Q-Exactive Orbitrap, Waters Xevo TQ-S and Sciex API 4000 Triple Quadrupoles; High-throughput PCR: ABI 7900, Quantstudio™ 12KFlex for qRT-PCR and digital PCR applications; Automated DNA/RNA QC, library handling and sample processing; dedicated IT infrastructure and bioinformatic applications for data analysis and interpretation.

Information about the CPGR can be obtained at www.cpgr.org.za and www.cpgr.org.za/blogspot.

For information, contact jo.mcbride@cpgr.org.za or lindsay.petersen@cpgr.org.za.